Formulation and Evaluation of Metoprolol Succinate Sustained Release Matrix Tablets
DOI:
https://doi.org/10.20372/mhsr.v1i1.83Keywords:
Ethocel, HPMC K4M, Matrix tablets, Sustained release, Wet granulation, Zero orderAbstract
Present study is intended to formulate and evaluate the metoprolol succinate sustained release matrix tablets to give efficient treatment of angina pectoris and to improve the patient compliance by reducing the frequency of dosage administration. Wet granulation method was used to prepare the metoprolol succinate sustained release matrix tablets using different ratios of Ethocel and HPMC K4M. Tablets were characterized for physical parameters, drug release behavior and optimized formulation was subjected to stability studies. In vitro drug release behavior was studied in 6.8 pH phosphate buffer USP type-II dissolution apparatus. The optimized formulation showed 99.24±1.32 % drug release in 24 hrs that clearly indicates the sustained drug release and the formulation F10 was showed good stability after three months. The drug release from above formulation followed zero order profile and the mechanism of drug release from matrix tablets followed non-Fickian release (diffusion and polymer relaxation). The results of this study suggest that combination of hydrophilic and hydrophobic polymers is a good approach to give sustained release profile when compared to that of individual polymers.
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