Pharmacological Activities of Streptomyces Species PO-178 178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India
Keywords:
Agumbe, Western Ghats, Anti- inflammatory, AnalgesicAbstract
In the present study, pharmacological activities namely anti-inflammatory, analgesic, antipyretic and CNS depressant activity of crude extract of Streptomyces species PO-178 isolated from Western Ghats soil of Agumbe, Karnataka, India have been studied. The isolate PO-178 was grown in starch casein nitrate broth medium. The culture filtrate was condensed to obtain crude extract. Anti- nflammatory, analgesic, antipyretic and CNS depressant activities of the crude extract were determined by Carrageenan-induced paw edema, tail flick, yeast induced pyrexia and spontaneous locomotor activity respectively. The extract exhibited dose dependent ant -inflammatory, analgesic, antipyretic and CNS depressant activity, however, the activities observed were lesser than standard drugs. Further studies are under progress to recover pharmacologically active principles from the extract of Streptomyces species PO-178 and to determine their activities.
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