Solution Equilibrium Study of the Complexation of Co(II) and Zn(II) with Nicotinaldehyde Thiosemicarbazone
Keywords:
Formation constant, Nicotinaldehyde thiosemicarbazone, Metal complexesAbstract
The interaction of nicotinaldehyde thiosemicarbazone with Co(II) and Zn(II) was investigated in SDS-water(1.15%w/v) at 303K and ionic strength of 0.1 mol dm–3. The speciation and stability constants of the metal complexes formed were determined by pH- metric method. Protonated and simple mononuclear species in different protonation and deprotonation states were identified. The corresponding formation constants calculated using MINIQUAD-75 computer program, and species distribution diagrams produced using the HYSS computer program. Selection of the best-fit chemical models was based on statistical parameters. The results obtained from the study revealed that, the NTSC on interaction with metal ions in solution, a series of mononuclear [M(LHh)] (h = 1, 0), and bis- mononuclear [M(L2Hh)] (h = 2, 1, 0,) species were identified.
Downloads
Metrics
References
Akinchan, N.T., Akinchan, R., Drozdzewski, P.M. (1996). Nuclear magnetic resonance and vibrational spectral
studies on platinum(II) complexes of thiosemicarbazone derived from fluorenone. Polish Journal of Chemistry 70(2): 171-179.
Alderighi, L., Gans, P., Ienco, A., Peters, D., Sabatini, A., Vacca, A. (1999). Hyperquad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species. Coordination Chemistry Review 184: 311-318.
Antholine, W., Knight, J., Whelan, H., Petering, D.H. (1977). Studies of the reaction of 2-formylpyridine thiosemicarbazone and its iron and copper complexes with biological systems. Molecular Pharmacology 13: 89-98.
Belicchi, M.F., Gasparri, G.F., Leporati, E.. Pelizzi, C., Tarasconi, P., Tosi, G. (1986). Thiosemicarbazones as co-ordinating agents. Solution chemistry and X-ray structure of pyridoxal thiosemicarbazone trihydrate and spectroscopic properties of its metal complexes. Journal of the Chemical Society, Dalton Transactions 11: 2455- 2462.
Belicchi, M.F., Giovanna, G.F., Corrado, P., Pieralberto, T. (1992). Thiosemicarbazones as co-ordinating agent. Part
Zinc complexes derived from methyl pyruvate and pyridoxal thiosemicarbazones. Journal of the Chemical Society, Dalton Transactions 14: 2153- 2160.
Beraldo, H. and Gambino, D. (2004). The wide pharmacological versatility of semicarbazones, thiosemicarbazones and their metal complexes. Mini- Reviews in Medicinal Chemistry 4: 31-39.
Brockman, R.W., Sidwell, R.W., Arnett, G., Shaddix, S. (1970). Heterocyclic thiosemicarbazones: correlation between structure, inhibition of ribonucleotide reductase, and inhibition of DNA viruses. Proceedings of the Society for Experimental Biology and Medicine 133: 609- 14.
Finch, R.A., Liu, M.C., Cory, A.H., Cory, J.G., Sartorelli, A.C. (1999). Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Advances in Enzyme Regulation 39: 3-12.
French, F.A., Blanz, E.J.J. (1965). The carcinostatic activity of alpha-(N) heterocyclic carboxaldehyde thiosemicarbazones. I. Isoquinoline-1-carboxaldehyde thiosemicarbazone. Cancer Research 25: 1454-8.
Gans, P., Sabatini, A. and Vacca, A. (1976). An Improved Computer Program for the Computation of Formation Constants from Potentiometric Data. Inorganica Chimica Acta 18: 237-239.
Giuseppe Arena., Enrico Rizzarelli., Silvio Sammartano. and Carmelo Rigano. (1979). A non-linear least-squares
approach to the refinement of all parameters involved in acid—base titrations. Talanta 26(1): 1-14.
Gran, G. (1950). Determination of the Equivalence Point in potentiometeric Titratins. Acta Chemica Scandinavica 4: 559-577.
Gran, G. (1952). Determination of the equivalence point in potentiometric titrations. Part II. Analyst 77: 661-671.
Hall, I.H., Lackey, C.B., Kistler, T.D., Durham, R.W. Jr,
Jouad, E.M., Khan, M., Thanh, X.D., Djebbar-Sid, S., Benali-Baitich, O., Bouet, G.M. (2000). Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines. Pharmazie 55(12): 937-41.
Hingorani, S., Agarawala, B.V. (1990). Structural investigations of Pd(II) and Pt(II) complexes with O- vanillin thiosemicarbazone and 4-
phenylthiosemicarbazone and their mixed ligand complexes. Spectroscopy Letters 23(8): 1097-1109.
Irving, H.M. and Rossotti, H.S. (1954). The Calculation of Formation Curves of Metal Complexes from pH-Titration Curves in Mixed Solvents. Journal of the Chemical Society (Resumed) 2904–2910
Irving, H.M. and Williams, R.J.P. (1948). Order of Stability of Metal Complexes. Nature (London) 162: 746-747.
Irving, H.M. and Williams, R.J.P. (1953). The stability of transition-metal complexes. Journal of the Chemical Society (Resumed) 167: 3192-3210.
Irving, H.M., Rossotti, H.S. (1953). Methods for computing successive stability constants from experimental formation Curves. Journal of the Chemical Society (Resumed) 3397–3405.
Kenie, D.N. and Satyanarayana, A. (2015). Protolitic Equilibria and Stability Constants of Mn (II) and Ni (II) Complexes of 3-formylpyridine Thiosemicarbazone in Sodium Dodecyl Sulphate(SDS-Water Mixture. Science, Technology and Arts Research 4(1): 74-79.
Ludwig, J.A., Szakács, G., Martin, S.E., Chu, B.F.,
Cardarelli, C., Sauna, Z.E., Caplen, N.J., Fales, H.M., Ambudkar, S.V., Weinstein, J.N., Gottesman, M.M. (2006). Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. Cancer Research 66(9): 4808-15.
Ma, B., Goh, B.C., Tan, E.H., Lam, K.C., Soo, R., Leong,
S.S., Wang, L.Z., Mo, F., Chan, A.T., Zee, B., Mok, T.
(2008). A multicenter phase II trial of 3-aminopyridine-2- carboxaldehyde thiosemicarbazone (3-AP, Triapine) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells. Invest New Drugs 26(2): 169-73.
Nutting, C.M., van Herpen, C.M.L., Miah, A.B., Bhide, S.A., Machiels, J.P., Buter, J., Kelly, C., de Raucourt, D., Harrington, K.J. (2009). Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma. Annals of Oncology 20(7): 1275-1279.
Offiong, O.E. (1994). Synthesis and spectral studies of platinum metal complexes of benzoin thiosemicarbazone. Spectrochimica Acta Part A: Molecular Spectroscopy 50A(13): 2167-2175.
Pal, I., Basuli, F., and Bhattacharya, S. (2002). Thiosemicarbazone complexes of the platinum metals. A story of variable coordination modes. Proceedings of the Indian Academy of Sciences: Chemical Sciences 114(4): 255-268.
Revathy, V., Palaniappan, R.A. (1990). Seletive and rapid spectrophotometric determination of platinum(II). Indian Journal of Chemistry: Section A 29: 197.
Sambasiva Rao, R., Satyanarayana, A. and Krishna Rao,
P.V. (1984). Procedings of the Summer Simulation Conference 563.
Shao, J., Zhou, B., Di Bilio, A.J., Zhu L., Wang T, Qi, C., Shih, J., Yen, Y. (2006). A Ferrous-Triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase. Molecular Cancer Therapeutics 5: 586-592.
Sushil (Nee Bathla), P., Srivastava, T.S. (1985). Platinum(II) complexes of cyclohexanone and cycloheptanone thiosemicarbazones. Indian Journal of Chemistry: Section A 24(3): 240 – 241.
Tempereni, M.L.A., Dos Santos, M.R., Paoli Monteiro, V.R. (1995). Spectroscopic study of the isomerization of Z- to E-pyridine-2-formyl thiosemicarbazone. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 51(9): 1517-1524.
West, D.X., Liberta, A.E., Padhye, S.B., Chikate, R.C.,
Sonawane, P.B., Kumbhar, A.S., Yerande, R.G. (1993). Thiosemicarbazone complexes of copper(I1): structural and biological studies. Coordination Chemistry Reviews123: 49-71.
Wu, C., Shukla, S., Calcagno, A.M., Hall, M.D., Gottesman, M.M., Ambudkar, S.V. (2007). Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter. Molecular Cancer Therapeutics 6: 3287-96.
Yuan, J., Lovejoy, D.B., Richardson, D.R. (2004). Novel di-2- pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment. Blood 104: 1450-1458.
Downloads
Published
How to Cite
License
Copyright (c) 2015 Journal of Science, Technology and Arts Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
STAR © 2023 Copyright; All rights reserved