Formulation, Development and Evaluation of Colon-specific Ketorolac Tromethamine Compression Coated Tablets

Authors

  • Sateesh Kumar Vemula Wallaga University
  • Selamu Kebamo Wallaga University
  • Biniam Paulos Wallaga University
  • Vijaya Kumar Bontha Jangaon Institute of Pharmaceutical Sciences

Keywords:

In vitro drug release, Microbial degradation, Pre-compression, Post-compression, Simulated gastrointestinal fluids, Upper gastrointestinal tract

Abstract

The major intention to formulate and develop colon targeted tablets is to improve the therapeutic efficacy by increasing therapeutic drug concentrations in colon. The present study was aimed to develop guar gum compression coated tablets ketorolac tromethamine to achieve the colon-specific drug release. In this study, both core and compression coated tablets were prepared by direct compression method. The prepared colon targeted tablets were characterized for different pre-compression and post- compression evaluations. In vitro drug release studies were performed by using USP XXIV Type II dissolution apparatus in simulated gastrointestinal fluids. From the in vitro dissolution studies, the formulation F4 showed 4.72±0.76% drug release in 5 h and it was progressively increased to 99.12±0.42% in 24 h that indicates retardation of drug release in stomach and small intestine and significant amount of drug release was observed in colonic environment. The accelerated stability studies proved the stability of guar gum compression coated tablets. From the above results, achievement of colon specific drug release might be due to substantial integrity of the compression coated guar gum in the upper gastrointestinal trac , but microbial degradation in the colon. In conclusion, development of microbial degradation compression coated tablets was suitable to target the ketorolac tromethamine to colon. Further the efficacy of the developed formulations has to be assessed by pharmacokinetic studies.

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Author Biographies

Sateesh Kumar Vemula, Wallaga University

Department of Pharmacy, College of Medical and Health Sciences, Wollega University, Post Box No: 395, Nekemte, Ethiopia

Selamu Kebamo, Wallaga University

Department of Pharmacy, College of Medical and Health Sciences, Wollega University, Post Box No: 395, Nekemte, Ethiopia

Biniam Paulos, Wallaga University

Department of Pharmacy, College of Medical and Health Sciences, Wollega University, Post Box No: 395, Nekemte, Ethiopia

Vijaya Kumar Bontha, Jangaon Institute of Pharmaceutical Sciences

Department of Pharmaceutics, Jangaon Institute of Pharmaceutical Sciences, Yeshwanthapur, Jangaon, Warangal-506167, Telangana, India

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Published

28.09.2015

How to Cite

Kumar , S., Kebamo, S., Paulos, B., & Kumar , V. (2015). Formulation, Development and Evaluation of Colon-specific Ketorolac Tromethamine Compression Coated Tablets. Journal of Science, Technology and Arts Research, 4(3), 150–154. Retrieved from https://journals.wgu.edu.et/index.php/star/article/view/259

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Original Research

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Plaudit