Anti-inflammatory Activity of Matricaria recutita L. against Acute and Chronic Inflammatory Models
Keywords:
German chamomile, Arthritis, Flavonoid, Freund’s adjuvant, PainAbstract
Chamomile (Matricaria recutita L.) is most popular used medicinal plant and extensively consumed as a tea and food. We investigated the effects of Matricaria recutita L. (MR) in acute and chronic inflammatory conditions. The anti-inflammatory activity of Matricaria recutita was studied against carrageenan induced hind paw, arachidonic acid, acetic acid and complete Freund’s adjuvant (CFA)-induced arthritis in rats. The methanol extract of Matricaria recutita was administered at the dose of 100, 200 and 300 mg/kg body weight. In CFA-induced model ESR, vascular permeability, histamine release from blood and biochemical parameters were carried out. Chamomile methanol extract showed dose dependent significant (P<0.001) anti-inflammatory activity by inhibition of rat paw oedema against carrageenan and arachidonic acid and inhibition of writhing induced by acetic acid. The significant anti-arthritic activity was observed with administration of Chamomile extract in the Freund’s adjuvant induced model of arthritis. Chronic treatment of extract of Chamomile showed significant decrease the development of arthritis and reduced ESR observed. It also reduced the histamine release from blood and vascular permeability at joint. The methanol extract of Matricaria recutita possess potential anti-
inflammatory activity against acute and chronic inflammatory model.
Downloads
Metrics
References
Bogdan, C. (2001). Nitric oxide and the immune response.Nature Immunology 2(10): 907-916.
Buch, M., Emery, P. (2002). The etiology and pathogenesis of rheumatoid arthritis. Hospital Pharmacy Journal 9: 5- 10.
Cai, X., Wong, Y.F., Zhou, H., Xie, Y., Jiang, Z.H., Bian, Z.X., Xu, H.X., Liu, L. (2006). The comparative study of Sprague-Dawley and Lewis rats in adjuvant induced arthritis. Naunyn-Schmiedeberg's Archives of Pharmacology 373(2): 140-47.
Chandrashekhar, V.M., Ranapariya, V.L., Ganapaty, S., Parashar, A., Muchandi, A.A. (2010). Neuroprotective activity of Matricaria recutita L against global model ischemia in rats. Journal of Ethanopharmacology 127(3): 645-51.
Corley, D.A., Kerhikowske, K., Verma, R., Baffler, D. (2003). Protective association of aspirin/NSAIDs and esophageal cancer. A systemic review and meta analysis. Gastroenterology 124(1):47-56.
Costa, M.D., Sutter, P.D., Gybel, J. (1981). Adjuvant induced arthritis in rats: A possible animal model of chronic pain. Pain 10(2):173-85.
Crunkhon, P., Meacock, S.C.R. (1971). Mediators of inflammation induced in the rat paw by carrageenan. British Journal of Pharmacology 42(3):392-402.
Dimartino, M.J., Griswold, D.E., Berkowitz, B.A., Poste, G., Lewis, A.J. (1987). Pharmacologic characterization of the anti-inflammatory properties of a new dual inhibitor of lipooxygenase and cyclo-oxygenase. Agents Actions 20: 113-23.
Franchis, Y.L., Hilda, L.W., Ethel, S.K.N. (2004). Time course and substance P effects on the vascular and morphological changes in adjuvant induced monoarthritis rats. International Immunopharmacology 4(2):299-310.
Holthusen, H., Arndt, J.O. (1994). Nitric oxide evokes pain in humans on intra-cutaneous injection. Neuroscience Letter 165(1-2):71-74.
Kalia, R., Rao, C.M., Kutty, N.G. (2007). Synthesis and evaluation of the anti-inflammatory activity of N[2-(3,5-di- tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl]- nicotinamide. Arznei-Forschung 57: 616-622.
Katz, L., Piliero, S.T. (1969). A study of adjuvant induced polyarthritis in the rat with special reference to associated immunological phenomena. Annals of the New York Academy of Sciences 147: 515-36.
Koster, R., Anderson, M., De Beer, E.J. (1959). Acetic acid for analgesic screening. Federation proceedings 18: 412.
Maria, M., Engeniusz, M., Miroslaw, K., Maria, K., Iwona, P. (1983). Adjuvant induced disease in rats, clinical findings and morphological and biochemical changes in the blood histological changes in internal organs. Rheumatology 2: 231-245.
Martens, D. (1995). Chamomile: the herb and the remedy. The Journal of the Chiropractice Academy of Homeopathy 6:15-18.
Motavalizadehkakhky, A. (2012). Antimicrobial activity and chemical composition of essential oils of chamomile from Neyshabur. Iranian Journal of Medicinal Plantsh Research 6: 820-24.
Newall, C.A., Anderson, L.A., Phillipson, J.D. (1996). Herbal medicines: A Guide For Healthcare Professionals. Pharmaceutical Press, London.
Prashith Kekuda, T.R., Onkarappa, R., Raghavendra, H.L. (2013). Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India. Science, Technology and Arts Research Journal 2(2): 83-91.
Prabhakar, K.R., Veerapur, V.P., Bansal, P., Vipan, K.P., Reddy, K.M., Barik, A., Reddy, B.K., Reddanna, P., Priyadarsini, K.I., Unnikrishnan, M.K. (2006). Identification and evaluation of antioxidant, analgesic/anti-inflammatory activity of the most active ninhydrin-phenol adducts synthesized. Bioorganic and Medicinal Chemistry 14(21):7113-7120.
Salaman, I. (1992). Chamomile: a medicinal plant. The Herb, Spice and Medicinal Plant Digest 10: 1-4.
Shore, P.A., Burkhalter, A., Cohn, V.H. (1959). A method for the flourimetric assay of histamine in tissues. Journal of Pharmacology and Experimental Therapeutics 127: 182-186.
Sims, J.E., Smith, D.E. (2010). The IL-1 family: regulators of immunity. Nature Reviews Immunology 10: 89-102.
Tomita, T., Yoshimi, K., Philip, S.T. (2006). THR-0921, a novel peroxisome proliferation-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis. Arthritis Research and Therapy 8(1):R7.
Trease, G.E., Evaans, W.C. (1989). Pharmacognosy, 13th ed.
Bailliere Tindall, London. 683-684.
Turner, R.A. (1965). Analgesics. In: Turner RA, (ed.), Screening Methods in Pharmacology. London: Academic Press, p. 100.
Van Eden, W., Holoshitz, J., Nevo, Z., Frenkel, A., Klazman, A., Cohen, I.R. (1985). Arthritis induced by a T- lymphocyte clone that responds to mycobacterium tuberculosis and to cartilage proteoglycans. Proceedings of the National Academy of Sciences USA 82(15):5117- 5120.
Vodovotz, Y., Kim, P.K., Bagci, E.Z., Ermentrout, G.B., Chow, C.C., Bahar, I., Billiar, T.R. (2004). Inflammatory Modulation of Hepatocyte Apoptosis by Nitric Oxide: In vivo, In vitro, and In Silico Studies. Current Molecular Medicine 4(7):753-62
Downloads
Published
How to Cite
License
Copyright (c) 2014 Journal of Science, Technology and Arts Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
STAR © 2023 Copyright; All rights reserved
