Rate and Predictors of Adherence to Antiretroviral Therapy among Clients on Antiretroviral Therapy at Tepi Health Center, South-west Ethiopia
Keywords:
Adherence, HAART, Rate and Predictors, HIV/AIDS, Combined AdherenceAbstract
Highly Active Antiretroviral Therapy (HAART) has resulted reduction of mortality and improved quality of life of peoples living with HIV/AIDS. Maximum benefits can only be achieved through maximum adherence. We designed this study to assess rate and predictors of adherence to antiretroviral therapy at Tepi health center. A facility based cross-sectional study was conducted through patient’s self report using structured pre-tested questionnaires and medical record of the clients in a total of 341 samples using systematic random sampling technique. The data were collected from January1, 2012 to February15, 2012 in Tepi health centre. The data was analyzed using SPSS version 16. Multiple logistic regression model was constructed to determine predictors of adherence. Self-reported dose adherence in the study area was 78.6% and that of combined indicator was 43.4%. Positive predictors of adherence includes alcohol drinking (AOR=4.36, 95% CI =2.03, 9.35), and a belief of ART cures HIV (AOR = 1.95, 95% CI = 1.21, 3.13) while long-duration on HAART (≥49 months) (AOR=0.29, 95%CI=0.11, 0.75) was negative predictor. The adherence rate in this study was much less than studies in many parts of Ethiopia. Interventions should target on reduction of alcohol use and on imparting appropriate knowledge of HAART that will address false beliefs of “ART cures HIV”.
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Amberbir, A., Woldemichael, K., Sofonias Getachew., Belaineh Girma and Kebede Deribe (2008). Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in Southwest Ethiopia." BMC Public Health 8: 265.
Arage, G., Tessema, G.A. and Hiwot Kassa (2014). Adherence to antiretroviral therapy and its associated factors among children at South Wollo Zone Hospitals, Northeast Ethiopia: a cross-sectional study. BMC Public Health 14(1): 365.
Biressaw, S., Abegaz, W.E., Markos Abebe, Workeabeba Abebe Taye and Mulugeta Belay (2013). Adherence to Antiretroviral Therapy and associated factors among HIV infected children in Ethiopia: unannounced home-based pill count versus caregivers' report. BMC Pediatrics 13: 132.
Cooke, C.E., Lee, H.Y. and Xing, S. (2014). Adherence to antiretroviral therapy in managed care members in the United States: a retrospective claims analysis. Journal of Managed Care Pharmacy 20(1): 86-92.
Deribe, K., Hailekiros, F., Biadgilign, S., Amberbir, A. and Beyene, B.K. (2008). Defaulters from antiretroviral treatment in Jimma University Specialized Hospital,
Southwest Ethiopia. Tropical Medicine & International Health 13(3): 328-333.
Dewing, S., Mathews, C., Geoffrey Fatti, Ashraf Grimwood and Andrew Boulle (2014). Antiretroviral adherence interventions in Southern Africa: implications for using HIV treatments for prevention. Current HIV/AIDS Reports 11(1): 63-71.
Edison, L., Hughes, D., Cherie Drenzek. and Jane Kelly. (2014). Prevalence and Indicators of Viral Suppression Among Persons with Diagnosed HIV Infection Retained in Care - Georgia. 2010. Morbidity and Mortality Weekly Report (MMWR) 63(3): 55-58.
Emiru, A. and Wakgari, D. (2014). Acceptability of Provider Initiated HIV Counseling and Testing among Tuberculosis and Non-tuberculosis Patients in Shashemene Town, Ethiopia. Science Technology and Arts Research Journal 3(1): 116-121.
Eyasu, E., Mengistu, L., Ameni, G. (2012). Preliminary Study on the Epidemiology of Tuberculosis in Nekemte and Its Surroundings -Western Ethiopia. Science Technology and Arts Research Journal 1(1): 18-25.
Gardner, E., Hullsiek, K., Telzak, E.E., Sharma, S., Peng, G., Burman, W.J., MacArthur, R.D., Chesney, M., Friedland,
G. and Mannheimer, S.B. (2010). Antiretroviral Medication Adherence and Class-Specific Resistance in a Large Prospective Clinical Trial. AIDS 24(3): 395-403.
Hassan, A. S., Nabwera, H.M., Shalton M. Mwaringa., Clare
A. Obonyo., Eduard, J. Sanders., Tobias F Rinke de Wit., Patricia A. Cane and James A. Berkley (2014). HIV-1 virologic failure and acquired drug resistance among first- line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study. AIDS Research Therapy 11(1): 9.
Kebede, A. and Wabe, N.T. (2012). Medication adherence and its determinants among patients on concomitant tuberculosis and antiretroviral therapy in South west Ethiopia. North American Journal of Medical Sciences 4(2): 67-71.
Lee, L., Rand, C.S., Ellen, J.M. and Agwu, A.L. (2014). Factors Informing HIV Providers' Decisions to Start Antiretroviral Therapy for Young People Living With Behaviorally Acquired HIV. Journal of Adolescent Health 55(3):358-365.
Maqutu, D., T. Zewotir, North, D., Naidoo, K. and Grobler, A. (2011). Determinants of optimal adherence over time to antiretroviral therapy amongst HIV positive adults in South Africa: a longitudinal study. AIDS Behavior 15(7): 1465-1474.
Markos, E., Worku, A. and Davey, G. (2008). Adherence to ART in PLWHA at Yirgalem Hospital, South Ethiopia. Ethiopian Journal Health Development 22(2).
Mathes, T., Pieper, D., Antoine, S.L. and Eikermann, M. (2013). Cost-effectiveness of adherence interventions for highly active antiretroviral therapy: a systematic review. International Journal of Technology Assessment in Health Care 29(3): 227-233.
Mengistu, Z. and Chere, A. (2012). Adherence to antiretroviral therapy and its associated factors among people living with HIV/AIDS in Addis Ababa, Ethiopia. Ethiopian Medical Journal 50(4): 355-361.
Michel, D., Lionel, P., Grappin, M., Forte, F., Peytavin, G., Buisson, M., Chavanet, P. and Portier, H. (2001). Evaluation of the Patient Medication Adherence Questionnaire As a Tool for Self-Reported Adherence Assessment in HIV-Infected Patients on Antiretroviral Regimens. HIV Clinical Trials 2(2): 128-135.
Miller, L. and Hays, R. (2000). Measuring adherence to antiretroviral medications in clinical trials. HIV Clinical Trials 1(1): 36-46.
Mirkuzie, A. H., Hinderaker, S.G., Sisay, M.M., Moland, K.M. and Mørkve, O. (2011). Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study. Journal of the International AIDS Society 14: 50.
Mulu, A., Liebert, U.G. and Melanie Maier (2014). Virological efficacy and immunological recovery among Ethiopian HIV-1 infected adults and children. BMC Infectious Diseases 14: 28.
Nelsen, A., Gupta, S., Trautner, B.W., Petersen, N.J., Garza, A., Giordano, T.P., Naik, A.D. and Rodriguez-Barradas,
M.C. (2013). Intention to adhere to HIV treatment: a patient-centred predictor of antiretroviral adherence. HIV Medicine 14(8): 472-480.
Bidhubhusan Mahapatra, Bharat Bhusan Rewari, Subhashish Sircar, Sandeep Rai, Srinivasan Venkatesh, Pinnamaneni Yujwal Raj, and Mohammed Shaukat (2013). Adherence to Antiretroviral Therapy and Its Effect on Survival of HIV- Infected Individuals in Jharkhand, India. PLoS ONE 8(6): e66860.
Tadios, Y. and Davey, G. (2006). Antiretroviral treatment adherence and its correlates in Addis Ababa, Ethiopia." Ethiopian Medical Journal 44(3): 237-244.
Talam, N. C., Gatongi, P.M., Rotich J.K. and Kimaiyo, S. (2009). Adherence to antiretroviral drug therapy by adult patients attending HIV/AIDS clinic at a Kenyan tertiary health institution. East African Medical Journal 86(5): 240- 243.
Tessema, B., Biadglegne, F., Andargachew Mulu., Assefa Getachew., Frank Emmrich and Ulrich Sack. (2010). Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross-sectional study. AIDS Research Therapy 7: 2.
Tiyou, A., Belachew, T., Fisehaye Alemseged and Sibhatu Biadgilign. (2010). Predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in resource-limited setting of southwest Ethiopia. AIDS Research Therapy 7: 39.
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