Flux Balance Analysis Based Model for the Identification of Potent Drug Target
A Novel Strategy
Keywords:
LPS, TLR4, FBA, TRAF6Abstract
The work aims at developing a strategy for the identification of potent drug target by analyzing signaling pathways. The strategy developed is designed and tested in concern with Toll Like Receptor Receptor-4 (TLR4) signalling pathway. TLR4 pathway is a major pathway which get trigger against Lipo- polysaccheride (LPS) stimulus. The work describes a strategy to identify potent drug targets by understanding the flow of information in signaling pathways by representing them in the form of stoichiometric matrices and analyzing mathematically by adopting relatively successful approaches, including flux balance analysis (FBA), Single Value Decomposition (SVD). The strategy successfully proposes TNF-α Receptor Associated Factor-6 Factor (TRAF6) as a potent drug target for LPS neutralization.
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