Cardio Protective Effect of Solanum nigrum Linn. in Isoproterenol Induc Induced Myocardial Infarction in Rat
DOI:
https://doi.org/10.4314/star.v4i4.11Keywords:
Cardio protective, Isoproterenol, Solanum nigrum, AntioxidantAbstract
Myocardial infarction is one of the highest confronting metabolic syndromes which cause morbidity and mortality across the world. Recently, the renewed interests in medicinal plants have certain preventive action in treatment of cardiovascular disorder. The aim of the study was to investigate the cardio protective effects of Solanum nigrum Linn (hydro alcoholic extract) in isoproterenol induced myocardial infarction. The extracts were investigated for in vivo cardio protective activity; the rats were pre treated with hydro alcoholic extract (75mg, 150mg and 300mg) for a period of 21 days. Standard drug (carvedilol - 2mg/kg) was used to compare the results with various parameters like bodyweight, ECG, heart weight, serum parameters and enzyme estimation. The rats fed with extracts showed dose dependent cardio protective activity. Isoproterenol treated animals showed a marked increase in serum marker enzymes such as CK- MB, LDH, cholesterol, triglycerides, SGOT, SGPT. It was also observed that there was substantial increase in heart and body weight along with endogenous enzyme levels of LPO. There was significant decrease in levels of SOD, CAT and GSH. Treatment group significantly reduced the effects of isoproterenol induced myocardial infarction. Solanum nigrum hydro alcoholic extract treated groups possess cardio protective effect against isoproterenol induced myocardial infarction.
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