Acetylcholinesterase Inhibitory Activity of Green Tea Polyphenols

Authors

  • Raghavendra H.L Wollega University
  • Prashith Kekuda T.R Kuvempu University
  • Farhath Khanum Defense Food Research Laboratory, Siddarthanagar

Keywords:

Green tea polyphenols, Acetylcholinesterase, Alzheimer’s disease

Abstract

Inhibition of acetylcholinesterase activity is one of the most popular approaches for treatment of neurological disorders such as Alzheimer’s disease and others. In the present study, we evaluated inhibition of acetylcholinesterase activity by different concentrations of green tea (Camellia sinensis L.) extract using acetylthiocholine as substrate. The green tea extract inhibited AChE activity dose dependently with an IC50 value of 42.05µg/ml. The observed inhibitory activity could be ascribed to the polyphenolic content of green tea extract. Consumption of green tea might provide protection against neurological disorders.

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Author Biographies

Raghavendra H.L, Wollega University

 

 

Prashith Kekuda T.R, Kuvempu University

 

 

Farhath Khanum, Defense Food Research Laboratory, Siddarthanagar

 

 

References

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Orhan, I., Naz, Q., Kartal, M., Tosun, F., Sener, B., Choudhary, M.I. (2007). In vitro anticholinesterase activity of various alkaloids. Verlag der Zeitschrift für Naturforschung 62c: 684-688.

Raghavendra, H.L., Kumar, P.S.V., Kekuda, P.T.R., Ejeta, E., Molla, B., Anilakumar, K.R., Khanum, F. (2011). HPLC method for chemical composition and in vitro antioxidant activity of Camellia sinensis Linn. Analytical Chemistry Letters 1(5 and 6): 361-369.

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Published

28.12.2014

How to Cite

Raghavendra H.L, Kekuda T.R, P., & Khanum, F. (2014). Acetylcholinesterase Inhibitory Activity of Green Tea Polyphenols. Journal of Science, Technology and Arts Research, 3(4), 141–142. Retrieved from https://journals.wgu.edu.et/index.php/star/article/view/530

Issue

Section

Short Communication

Categories

Plaudit

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