Cytotoxic Activity of Croton gibsonianus Nimm. Grah

Authors

  • Prashith Kekuda T.R SRNMN College of Applied Sciences
  • Raghavendra H.L Wallaga University
  • Vinayaka K.S Kuvempu University

Keywords:

Croton gibsonianus, LC50, Brine shrimp lethality

Abstract

The present study was designed to investigate the cytotoxic activity of methanol extract of Croton gibsonianus Nimm. Grah (Euphorbiaceae) leaves by brine shrimp lethality bioassay. The powdered leaf material was extracted with methanol. The cytotoxicity activity of methanol extract was tested using brine shrimp (Artemia nauplii) lethality assay. The mortality of shrimps were determined and LC50 was calculated. Cytotoxic activity, in terms of mortality of brine shrimps, was dependent on concentration of the extract. Highest mortality (87%) was observed at extract concentration 1000μg/ml. The LC50 of methanol extract was found to be 109.48μg/ml. The result of the study indicated that the extract possesses cytotoxic property. Further studies on isolation of active constituents possessing cytotoxic activity their cytotoxicity on various cancer and tumor cell lines are under investigation.

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Author Biographies

Prashith Kekuda T.R, SRNMN College of Applied Sciences

Department of Microbiology, SRNMN College of Applied Sciences, NES Campus, Balraj Urs Road, Shivamogga-577201, Karnataka, India

Raghavendra H.L, Wallaga University

Faculty of Medical Sciences, Wollega University, Post Box No: 395, Nekemte, Ethiopia.

Vinayaka K.S, Kuvempu University

Department of PG Studies and Research in Botany, Kuvempu University, Jnanasahyadri, Shankaraghatta-577451, Karnataka, India.

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Published

30.03.2012

How to Cite

Kekuda T.R, P., H.L, R., & K.S, V. (2012). Cytotoxic Activity of Croton gibsonianus Nimm. Grah. Journal of Science, Technology and Arts Research, 1(1), 57–59. Retrieved from https://journals.wgu.edu.et/index.php/star/article/view/19

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Section

Short Communication

Categories

Plaudit

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