Pharmacological Activities of Streptomyces Species PO-178 178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

Authors

  • Prashith Kekuda TR Kuvempu University
  • Onkarappa R Kuvempu University
  • Raghavendra HL Wallaga University

Keywords:

Agumbe, Western Ghats, Anti- inflammatory, Analgesic

Abstract

In the present study, pharmacological activities namely anti-inflammatory, analgesic, antipyretic and CNS depressant activity of crude extract of Streptomyces species PO-178 isolated from Western Ghats soil of Agumbe, Karnataka, India have been studied. The isolate PO-178 was grown in starch casein nitrate broth medium. The culture filtrate was condensed to obtain crude extract. Anti- nflammatory, analgesic, antipyretic and CNS depressant activities of the crude extract were determined by Carrageenan-induced paw edema, tail flick, yeast induced pyrexia and spontaneous locomotor activity respectively. The extract exhibited dose dependent ant -inflammatory, analgesic, antipyretic and CNS depressant activity, however, the activities observed were lesser than standard drugs. Further studies are under progress to recover pharmacologically active principles from the extract of Streptomyces species PO-178 and to determine their activities.

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Author Biographies

Prashith Kekuda TR, Kuvempu University

Post Graduate Department of Studies and Research in Microbiology, Kuvempu University, Sahyadri Science College campus, Shivamogga Shivamogga-577203, Karnataka, India

Onkarappa R, Kuvempu University

Post Graduate Department of Studies and Research in Microbiology, Kuvempu University, Sahyadri Science College campus, Shivamogga Shivamogga-577203, Karnataka, India

Raghavendra HL, Wallaga University

College of Health and Medical Sciences, Wollega University, Post Box No: 395, Nekemte, Ethiopia

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Published

30.06.2013

How to Cite

Kekuda TR, P., R, O., & HL, R. (2013). Pharmacological Activities of Streptomyces Species PO-178 178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India. Journal of Science, Technology and Arts Research, 2(2), 83–91. Retrieved from https://journals.wgu.edu.et/index.php/star/article/view/128

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