Acetylcholinesterase Inhibitory Activity of Green Tea Polyphenols
Keywords:
Green tea polyphenols, Acetylcholinesterase, Alzheimer’s diseaseAbstract
Inhibition of acetylcholinesterase activity is one of the most popular approaches for treatment of neurological disorders such as Alzheimer’s disease and others. In the present study, we evaluated inhibition of acetylcholinesterase activity by different concentrations of green tea (Camellia sinensis L.) extract using acetylthiocholine as substrate. The green tea extract inhibited AChE activity dose dependently with an IC50 value of 42.05µg/ml. The observed inhibitory activity could be ascribed to the polyphenolic content of green tea extract. Consumption of green tea might provide protection against neurological disorders.
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Cabrera, C., Artacho, R., Giménez, R. (2006). Beneficial effects of green tea- a review. Journal of the American College of Nutrition 25(2):79-99.
Chacko, S.M., Thambi, P.T., Kuttan, R., Nishigaki, I. (2010). Beneficial effects of green tea: A literature review. Chinese Medicine 5:13.
Jo, Y., Yuk, H., Lee, J., Kim, J., Kim, R., Lee, S. (2012). Antioxidant, tyrosinase inhibitory and acetylcholinesterase inhibitory activities of green tea (Camellia sinensis L.) seed and its pericarp. Food Science and Biotechnology 21(3): 761-768.
Lu, S., Wu, J.W., Liu, H., Zhao, J., Liu, K., Chuang, C., Lin, H., Tsai, W., Ho, Y. (2011). The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies. Journal of Biomedical Science 18: 8.
Mukherjee, P.K., Kumar, V., Mal, M., Houghton, P.J. (2007). Acetylcholinesterase inhibitors from plants. Phytomedicine 14: 289-300.
Ohran, I., Kartal, M., Kan, Y., Sener, B. (2008). Activity of essential oils and individual components against acetyl and butyrylcholinesterase. Verlag der Zeitschrift für Naturforschung 63c: 547-553.
Okello, E.J., Leylabi, R., McDougall, G.J. (2012). Inhibition of acetylcholinesterase by green and white tea and their simulated intestinal metabolites. Food and Function 3(6):651-661.
Orhan, I., Naz, Q., Kartal, M., Tosun, F., Sener, B., Choudhary, M.I. (2007). In vitro anticholinesterase activity of various alkaloids. Verlag der Zeitschrift für Naturforschung 62c: 684-688.
Raghavendra, H.L., Kumar, P.S.V., Kekuda, P.T.R., Ejeta, E., Molla, B., Anilakumar, K.R., Khanum, F. (2011). HPLC method for chemical composition and in vitro antioxidant activity of Camellia sinensis Linn. Analytical Chemistry Letters 1(5 and 6): 361-369.
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